Lead Actress Bails Out on Struggling NBC Comedy LA Times

A struggling NBC comedy series has suffered another setback with the departure of its lead actress. The Los Angeles Times' Show Tracker reports that Christina Applegate has departed "Up All Night."

"[T]he show has taken a different creative direction and I decided it was best for me to move on to other endeavors," Applegate said in a statement.

The comedy received an overhaul recently, and has been dealing with behind-the-scenes upheaval including the departure of creator Emily Spivey and a "revolving door of showrunners," the story says.

The show was originally designed to mine the humor of new parenthood, but recently had focused more on Applegate's character's work at an Oprah-like talk show hosted by Maya Rudolph's character. It was thought that the change was designed to provide more screen time to Rudolph, and that the show might add more of that element as it switched from a single-camera comedy into a multicam production, the story says.

"So how does a show about juggling parenthood go on without one of the parents? It's unclear how, or whether, the show will continue after Applegate's departure. Production, set to begin this month, had not yet started on new episodes," the piece notes.

NBC didn't return a call for comment, the story adds.