When the "Comedy Central Roast of Charlie Sheen" airs Monday, Sept. 19, at 10 p.m. ET — the same night as CBS’s season premiere of the Charlie Sheen-less "Two and a Half Men" — the host of the roast will be Fox animation domination scribe Seth MacFarlane, reports TheWrap.com.

The creator of "American Dad" and "Family Guy" was announced today as the master of ceremonies. In a statement, MacFarlane said: "I’m very excited to work with Comedy Central again on the roast. Charlie is a true icon with a talent that is strong and pure and concentrated into small crystals, which can be smoked or eaten.”

This will be MacFarlane’s third time as a toastmaster on the program.