In the first recasting announcement of the current cycle for a network show picked up to series, an NBC sitcom is set to get a new female lead, Deadline.com reports. Irish actress Amy Huberman is out as the lead in the single-camera comedy “Animal Practice,” the story reports.

The show stars Justin Kirk as George, a veterinarian who loves animals but hates their owners. In the pilot, Huberman played his ex-girlfriend, who is assigned to run the clinic, the story says. The actress won the role in her first U.S. audition. Huberman’s replacement has not been announced.

Tyler Labine and Bobby Lee also star in the series, which is part of a batch of single-camera sitcoms in the works at NBC.

As we reported earlier this week, “Animal Practice” was added to NBC’s lineup for 2012-13 along with the White House comedy “1600 Penn.” The shows join "Save Me," starring Anne Heche; "The New Normal" from "Glee" co-creator Ryan Murphy; the comedy "Go On," with Matthew Perry; and the drama "Revolution," from J.J. Abrams, on NBC’s upcoming schedule.