CBS once again was the top network in terms of total viewers and among the adults 18 to 49 demographic, but for the week of Nov. 22-28, ABC’s “Desperate Housewives” was the No. 1 show in total viewers and the key demo.

The Sunday night mystery serial scored a 12.5 rating in adults 18 to 49 for the tenth week of the season, according to Nielsen Media Research. A Thanksgiving night airing of CBS’s flagship franchise “CSI” was second for the week, scoring an 8.4, followed by sister procedural “CSI: Miami” (8.1), ABC’s reality offering “Extreme Makeover: Home Edition” (7.5) and CBS comedy “Two and a Half Men” (6.8).

Among total viewers, the top three spots were the same as the demo-“Desperate Housewives” was ranked highest for the week with 27.24 million, followed by “CSI” (24.38 million) and “CSI: Miami” (22.12 million). CBS’s “Without a Trace” came in fourth with 19.79 million, while “Two and a Half Men” mirrored its adults 18 to 49 performance with fifth place (18.94 million).

ABC’s strength came at the expense of NBC, which dropped from a second-place position last week in viewers and in the demo to third place for week 10.

CBS was No. 1 for the week in adults 18 to 49 with a 4.2, followed by ABC (4.1), NBC (3.6), Fox (2.9) and the WB and UPN (tied with a 1.4).

Among total viewers CBS garnered 13.91 million, followed by ABC (11.05 million), NBC (10.02 million), Fox (7.47 million), The WB (3.93 million) and UPN (3.40 million).