(Corrects her new title)

Angela Shapiro-Mathes is leaving Fox Television Studios to run TLC.

The FTVS president will take the title of president and general manager of the lifestyle cable network, announced David Zaslav, president and CEO of Discovery Communications, at Discovery’s Los Angeles upfront presentation.

Ms. Shapiro-Mathes replaces David Abraham, who left the network amid a companywide executive shakeup in February. Starting July 1, she will manage TLC from Los Angeles, effectively turning TLC into the first bicoastal network for the Silver Spring, Md.-based Discovery Communications.

Ms. Shapiro-Mathes will be charged with deepening TLC’s relationships with the creative community.

“With an enormous depth of experience running Fox Television Studios, ABC Family and ABC Daytime, Angela has a record of achievement that few can match,” said Mr. Zaslav, to whom Ms. Shapiro-Mathes will report. “Key to all these positions is her unique ability to create content and brands and broker advertising, new-media and marketing partnerships.”

Ms. Shapiro-Mathes has run FTVS since 2004. During her tenure, she has ramped up scripted series development: This spring and summer, the studio has three new scripted series: “The Riches” on FX, “Burn Notice” on USA and “Saving Grace” on TNT, in addition to the return of “The Shield” on FX.

Before joining Fox, Ms. Shapiro-Mathes was president of ABC Family Channel.

(Editor: Horowitz)