One of NBC’s most high-profile new series for fall has had a shakeup behind the cameras. Writing for EW.com’s Inside TV, James Hibberd reports that showrunner Ed Bernero, whose resume includes “Criminal Minds” and “Third Watch,” is departing the Katherine Heigl spy thriller “State of Affairs.”

“Showrunner changes are not entirely uncommon during the run-up to a series launch and one source close to the project said Bernero had creative differences with fellow executive producer Joe Carnahan,” Hibberd notes. “The source further claimed the exit doesn’t have anything to do with the show’s star — who previously departed ABC’s hit ‘Grey’s Anatomy’ under contentious circumstances.”

Heigl has been fending off accusations for a few years that she’s difficult to work with, and addressed the issue with reporters at last month’s Television Critics Association press tour.

“On the new drama, Heigl plays Charleston Tucker, a CIA analyst who advises the president (Alfre Woodard) on international security while balancing her complicated personal life,” Hibberd writes. “Writer-producer Dario Scardapane (FX’s ‘The Bridge’) is in talks with NBC to take over showrunner duties on the series.”

The show is slotted for Monday nights on NBC starting Nov. 17, leading out from “The Voice.”

Katherine Heigl